We believe in empowering your active life. Our botanists meticulously craft topical solutions designed to work with your body, offering targeted support for daily comfort and a renewed sense of well-being. Explore how our unique blends help you bounce back.

Find Your Comfort: Topical Blends for Daily Soreness Support Kannaco: Topical Comfort for Daily Life Discover how our expertly crafted topical blends bring everyday comfort. We believe in supporting your daily well-being naturally. Our botanists carefully select ingredients like CBD and CBG, combining them to create topical solutions designed to help you move freely and feel your best. This guide explores how these plant-powered compounds work with your body, focusing on how our unique formulations deliver targeted support right where you need it. Learn about the science behind our soothing creams and roll-ons, and why quality and thoughtful ingredient combinations are key to your comfort. Explore Our Topical Solutions

Unlock Your Body's Natural Comfort & Recovery The Science Behind Our Targeted Topical Support Kannaco: Topical Comfort for Active Lifestyles Discover how our expertly formulated topical creams support your body's natural recovery. We blend botanicals for everyday comfort and well-being. Body paragraph: We believe in empowering your active life. Our botanists meticulously craft topical solutions designed to work with your body, offering targeted support for daily comfort and a renewed sense of well-being. Explore how our unique blends help you bounce back. CTA: Explore Our Creams Product description: Our Pro Cream is a cornerstone of daily comfort, expertly formulated to support your body's natural recovery process. We blend premium botanicals, leveraging their synergistic properties to deliver targeted benefits. This rich, emollient cream absorbs beautifully, leaving your skin feeling nourished and your body ready to embrace each day with renewed vitality. It's our commitment to helping you maintain an active, comfortable lifestyle.

Our botanists carefully select floral hemp plant varieties to extract Cannabidiol (CBD) and Cannabigerol (CBG). These non-psychoactive compounds are key to our topical blends, offering targeted support for your daily comfort and recovery.

Our botanists craft each topical blend, combining CBD and CBG to support your body's natural systems. We detail how these key ingredients work together, offering targeted relief for daily discomfort and active recovery. Discover the science behind our formulas and how they enhance your well-being.

How Our Botanicals Work with Your Body's Natural Systems

We carefully select premium hemp, cultivated either indoors in biosesupport environments or sun-grown when nature offers its best. Our botanists ensure each plant meets our high standards, yielding non-intoxicating CBD and CBG. We then use precise CO2 extraction, a high-pressure, sub-zero process, to sesupport the pure compounds for our formulas. 

The extraction process really depends on the operators and their patience and care when isolating and extracting the different chemical compounds within that specific plant variety and crop. Great operators generally employ a gentler multi-phase process to preserve terpenes, flavonoids, and cannabinoids. 

These hemp-derived cannabinoids also known as phytocannabinoids engage and interact with your endocannabinoid system, which plays a natural, automatic, and systemic role in maintaining homeostasis among your body's core operating systems, from peripheral tissue (your organs) to your central nervous system, your ECS (endocannabinoid system) plays a role.

Within your ECS, there are two primary sensors (receptors) that CBD and CBG interact with. The cellular activity modulated from these interactions is synergistic as each cannabinoid yields a slightly different response. 

For example, the cannabinoid Delta 9 THC actually binds and sticks to these receptors whereas CBD and CBG work with the receptors to modulate and activate other cellular activity such as increasing production of neurotransmitters or prohibiting the production of counterproductive enzymes and acids. 

The receptors are known as CB1 and CB2.

Both receptors are located within and can be found in both your brain and your peripheral tissues. However, CB1 receptors have the highest concentration in the brain and central nervous system, where they influence neurotransmission and mood, while CB2 receptors have a higher concentration in the immune system and peripheral tissues, where they have the potential to engage with discomfort and temporary irritation signals without producing psychoactive effects. 

CBD (cannabidiol) is widely studied for its influence on CB2 receptors, which are abundant in the peripheral tissue, skin and immune system.

CBG (cannabigerol) interacts with both CB2 and CB2 receptors broadening the potential for its therapeutic impact. It is often referred to as the “mother of cannabinoids” because many other cannabinoids (including CBD and THC) are derived from its precursor, cannabigerolic acid (CBGA). 

Where Ancient Wisdom Meets Modern Research

Remedies with use of CBD and CBG possess deep cultural roots spanning millennia.

According to publication by the national Library of Medicine, titled: "Cannabis in Chinese Medicine: Are some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?": 

The earliest documented medicinal use of cannabinoids dates back to ancient China, where it was first described in the Shen Nung Pen-ts'ao Ching (The Divine Farmer's Materia Medica), a foundational text attributed to Emperor Shen Nung around 2700 BCE. This ancient pharmacopoeia classified the cannabinoids from hemp plants as "superior herbs" and documented its applications for various ailments, including relief from physical discomfort and skin conditions.

Read the full publication here

Ancient Chinese physicians like Sun Simiao (581-683 AD) documented using crushed cannabis leaves to extract juice for support physical discomfort from fractured bones. By 1070 AD, the Song Dynasty's Illustrated Classic of Materia Medica included detailed cannabinoid preparations for physical discomfort.

Modern Cannabinoid Discovery

The modern understanding of individual cannabinoids began taking shape in the mid-20th century. CBD was first isolated by Harvard chemist Roger Adams in 1940, though its complete chemical structure wasn't determined until 1963 by Dr. Raphael Mechoulam and colleagues. CBG was subsequently discovered and isolated by Dr. Raphael Mechoulam and Dr. Yehiel Gaoni in 1964.

The pivotal discovery of the endocannabinoid system revolutionized cannabinoid research. CB1 receptors were first cloned in 1990, followed by CB2 receptors in 1993. This breakthrough revealed why humans possess receptors capable of responding to plant cannabinoids, leading to the identification of endogenous cannabinoids like anandamide in 1992.

The Science of Topical Cannabinoids

Modern research demonstrates that topically applied CBD and CBG bypass first-pass metabolism and interact locally with endocannabinoid system (ECS) receptors in the skin without entering systemic circulation in significant amounts. This localized action makes them ideal for targeted applications.

Citing an article from Dermatology Times titled: "CBD and CBG Ointment Improved Skin in Patients with Atopic Dermatitis"

Recent clinical studies have validated several potential benefits of topical cannabinoids. A 2022 study published in Molecules demonstrated that 0.1% CBG serum significantly reduced swelling and redness in human subjects with contact dermatitis, outperforming placebo support. The study showed CBG returned skin condition to near-baseline levels after just two weeks of application.

The same clinical trial found that CBG-support sites produced statistically significant lower transepidermal water loss (TEWL) values compared to unsupported and placebo sites, demonstrating improved skin barrier function. Gene array analysis using 3D human skin models revealed that CBG outperforms CBD in targeting key genes related to collagen, elastin, and skin hydration.

Research published in 2022 using parallel artificial membrane permeability assays (PAMPA) and Franz cell diffusion studies confirmed CBD's favorable skin permeability profile, with computational predictions showing -Log Kp values of 3.6-5.7 cm/s. CBD demonstrated similar permeability characteristics to known skin-permeable compounds like verapamil and progesterone. Franz cell diffusion studies show CBD reaches detectable levels within 30 minutes of application and maintains steady-state concentrations of 47.6-51.8 μg/mL from 6-12 hours post-application.

Health & Wellness Alignment 

Current research supports diverse applications for CBD and CBG in topical formulations. Recent studies have documented effectiveness in support atopic dermatitis, with CBD-infused formulations significantly improving severity scores and reducing pruritus in clinical trials.

Formulation Stability: Studies have shown that CBD solubility can reach 378.4 μg/mL in surfactant Tween 20, with stability maintained at 81% and 70% over 30 days in acidic environments (pH 5-6). This research indicates that maintaining products at slightly acidic pH levels helps preserve cannabinoid integrity.

Enhanced Delivery Systems: Recent advances include nanoformulated CBD for improved skin penetration and bioavailability, microneedle patches for enhanced transdermal delivery, and specialized hydrogels that demonstrate superior properties.

Clinical safety studies demonstrate that CBG is non-irritating at concentrations up to 3% when tested using 3D human skin equivalents. Multiple clinical trials report minimal adverse effects, supporting the safety profile of topical cannabinoids when properly formulated.

Quality control remains crucial for therapeutic efficacy. Research emphasizes the importance of third-party laboratory testing for cannabinoid content verification, standardized extraction methods such as supercritical CO2 extraction, and appropriate formulation pH (5-6) for optimal stability.

Current Clinical Evidence

A 2024 systematic review identified five ongoing clinical trials evaluating CBD for dermatological applications, including studies on acne vulgaris, atopic dermatitis, and severe pruritus. Preliminary results show promising safety and tolerability profiles across various applications.

Research confirms that topical cannabinoids achieve therapeutic concentrations in skin tissue without significant systemic absorption, making them suitable for localized support while minimizing potential side effects.

CBD and CBG Applications in Topical Products

CBD and CBG represent a convergence of ancient wisdom and modern science in topical therapeutics. Historical documentation spanning over 4,700 years, combined with contemporary clinical research, supports their potential applications in dermatology and skincare. Current evidence from peer-reviewed studies demonstrates comfort-supporting, antioxidant, and skin barrier-enhancing properties, with CBG showing particular promise in recent clinical trials.

As research continues to expand, with multiple clinical trials currently underway, these cannabinoids offer evidence-based, non-intoxicating options for topical therapeutic applications. However, continued clinical investigation and standardized quality control remain essential for maximizing their therapeutic potential.

Conclusion

CBD and CBG are promising compounds in the realm of topicals. Understanding their history, science, and applications can help consumers make informed choices. As research continues, these compounds may offer new insights into skin health and wellness.

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. These products are not intended to identify, support, support, or prevent any wellness concern.

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